Basic Information
VIS ID
TVIS44007068
Fusion event
HTLV-1-TONSL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145655517/144430134 (Hg38)
End
145655517/144430134 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
TONSL
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-92a-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6727-3p ; hsa-mir-1203
Nearest miRNA
hsa-mir-1204/Upstream/29789; hsa-mir-10400/Downstream/5417;
Nearest TSS
ENST00000518652/Upstream/1571; ENST00000442850/Downstream/7541;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/707, chr8-CpG: 18/Downstream/6626
Upstream sequence
CCCTGCCAGGAAGTAGGAGGGTCCCTTGGCAGCTTTCAACACCCTGACCTTGGGATCCCTTTTCCTGCCAGGGACAAGAAGAAAGTCCCTGTGGAACAGG
Downstream sequence
GTCTTGCCTACCATAGTCTGCTCTGAAGGTTGGGTTGGAGAGACCAGAGGCAGATACCCACCTCGCCCCCTAACCCATGGTTTTAGGAGCTGGGATCATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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