Basic Information
VIS ID
TVIS44007124
Fusion event
HTLV-1-UBE3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25675572/25430425 (Hg38)
End
25675572/25430425 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE3A
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-944 ; hsa-mir-5007-3p ; hsa-mir-6739-3p ; hsa-mir-6853-3p ; hsa-mir-1206 ; hsa-mir-3613-3p ; hsa-mir-5692b ; hsa-mir-5692c ; hsa-mir-369-3p ; hsa-mir-541-5p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-1268a/Upstream/1868294; hsa-mir-10393/Downstream/418322;
Nearest TSS
ENST00000557528/Upstream/9692; ENST00000557558/Downstream/7904;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/474518, chr15-CpG: 143/Downstream/7823
Upstream sequence
atatatataatacatatatataAGATAAATACTATTGTAGCAGGGCAATTTTGGACAAATACTAGGTTATCTGAAACAGCACTTTGGGGAATTAGATCTT
Downstream sequence
GACCATTTAAGAGAGAGATTAGCCCCAGTTTCTCAAAATCTGGCACTGACTAGCAATATGGACAATGTGTGCACCGCCCTCGTTCCACCTCCCCTCCTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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