Basic Information
VIS ID
TVIS44007126
Fusion event
HTLV-1-MYO9A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
72278947/71986606 (Hg38)
End
72278947/71986606 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO9A
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-let-7c-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10393/Upstream/1907138; hsa-mir-11181/Downstream/600611;
Nearest TSS
ENST00000557528/Upstream/14400; ENST00000567794/Downstream/59376;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/174528, chr15-CpG: 112/Downstream/130915
Upstream sequence
aacagggatccctaatctcacgaaaaattcatattatctactgacgtcTtgatcctgaccctgtgtaggcctatgctaatatgctatggtaatatgtatg
Downstream sequence
tatacatgctaacatgtatgtatgtgtctttgcttttaacaaaaaagtttttaaagttttaaaaaattttaatagaaagagggcttataattatataaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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