Basic Information
VIS ID
TVIS44007156
Fusion event
HTLV-1-SNAP25-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
10090527/10109879 (Hg38)
End
10090527/10109879 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA20B
Target gene
SNAP25-AS1
Nearest miRNA
hsa-mir-103a-2/Upstream/2738187; hsa-mir-1-1/Downstream/539757;
Nearest TSS
ENST00000382410/Upstream/74555; ENST00000458004/Downstream/63641;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/74613, chr20-CpG: 35/Downstream/62241
Upstream sequence
AAGAACACTGCTGCAACTTCAGACTTCAGGTCAATTACTATTGACTGGCCAACTTTCTGTCCCGAGCATACCCTCTTGGGTCCAATTCCAGATTAATAAT
Downstream sequence
GGCCCAATTCCAAATCTGGAGGATTCCTGGCCTCTCTCTCTCTCTCTCTTTCAATGCAGTTGCTTACTTCCCTTAAGACTGGCTCTGAATATACAAGAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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