Basic Information
VIS ID
TVIS44007169
Fusion event
HTLV-1-CRYBG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
97548516/97829672 (Hg38)
End
97548516/97829672 (Hg38)
Orient
+
Location type
Intronic
Target gene
CRYBG3
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-4771 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-548l ; hsa-mir-548n
Nearest miRNA
hsa-let-7g/Upstream/1469633; hsa-mir-12124/Downstream/2134642;
Nearest TSS
ENST00000440867/Upstream/7632; ENST00000495403/Downstream/45019;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/6883, chr3-CpG: 77/Downstream/142269
Upstream sequence
TTAGAAAGATTTATATTTTATTGGAAAAGTCACATATGAAAATGCTTTGGTTAATTCTTCCATGTGATCCTAACATTTTGGTTATTTGATTTGAAAGCTT
Downstream sequence
CACCTGTGtttaaaaagaattaatttagtgtcgctgtgtcaagcaccagtctaggtcctgggaatccagcagttaacaaggtgcagcattgtctttgcct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate