Basic Information
VIS ID
TVIS44007188
Fusion event
HTLV-1-MAP3K1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
56127848/56832021 (Hg38)
End
56127848/56832021 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
MAP3K1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-423-3p ; hsa-mir-125a-5p ; hsa-let-7g-5p ; hsa-mir-34a-5p ; hsa-let-7a-5p ; hsa-mir-193a-3p ; hsa-mir-193b-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-153-5p ; hsa-mir-3646 ; hsa-mir-4762-3p ; hsa-mir-4539 ; hsa-mir-1252-3p ; hsa-mir-5585-3p ; hsa-mir-4703-3p ; hsa-mir-509-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-323a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-451a
Nearest miRNA
hsa-mir-10397/Upstream/1323095; hsa-mir-103a-1/Downstream/1698022;
Nearest TSS
ENST00000502646/Upstream/16447; ENST00000469188/Downstream/30143;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14939, chr5-CpG: 113/Downstream/77114
Upstream sequence
CTTTTAGCTGTTGGAGAGGGAATTGCCAGGTGTCTTTAGTGGAAAGATATTTAACCTGCTGTCTGACTGCTTATtgtggtagatgaagtgttagcactgg
Downstream sequence
ctcaggcttgtgagaccgttccccattactgtcctaacactttggcaggattttgagtaaagttactttatttaacctcttttgagtttgacctcatcta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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