Basic Information
VIS ID
TVIS44007198
Fusion event
HTLV-1-OGDH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44715379/44675780 (Hg38)
End
44715379/44675780 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
OGDH
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-361-5p ; hsa-mir-552-5p ; hsa-mir-4326 ; hsa-mir-1293 ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-151a-5p ; hsa-mir-151b ; hsa-mir-1914-3p ; hsa-mir-2278 ; hsa-mir-2467-3p ; hsa-mir-3141 ; hsa-mir-4419a ; hsa-mir-4468 ; hsa-mir-4483 ; hsa-mir-4510 ; hsa-mir-4651 ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4779 ; hsa-mir-5194 ; hsa-mir-608 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6738-5p ; hsa-mir-6782-5p ; hsa-mir-6785-5p ; hsa-mir-6873-5p ; hsa-mir-6883-5p ; hsa-mir-891a-3p ; hsa-mir-4712-3p
Nearest miRNA
hsa-mir-1183/Upstream/564868; hsa-mir-10399/Downstream/205968;
Nearest TSS
ENST00000635602/Upstream/8985; ENST00000492001/Downstream/72801;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/68556, chr7-CpG: 131/Downstream/72644
Upstream sequence
cagcctgaccaacatggagaaaccccatctctactaaaaatacaaaattagccgggcgtggtggcgcatgcctgtaatcccagctactcgggaggctgag
Downstream sequence
gcaggagaatcgcttgaacccagaaagtggaggttgcagtgagccgagatcgcgccattgcactccaacctgggcaacaagagcgaaactccatctcaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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