Basic Information
VIS ID
TVIS44007212
Fusion event
HTLV-1-SH3GL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
17785854/17785856 (Hg38)
End
17785854/17785856 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9G
Target gene
SH3GL2
miRNAs that regulate target gene
hsa-mir-330-3p ; hsa-mir-26b-5p ; hsa-mir-107
Nearest miRNA
hsa-mir-101-2/Upstream/11777952; hsa-let-7a-1/Downstream/787450;
Nearest TSS
ENST00000422679/Upstream/206733; ENST00000636209/Downstream/120707;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/206050, chr9-CpG: 95/Downstream/120565
Upstream sequence
AATTTTCTCTAGTTATGTGCTGGAGAAGTGATTAAGTCTTTTAAATGAACACAGTATTTTTGCTCTTCATGGGTCTGTTTACCATCAGAATCTTAGTTGA
Downstream sequence
GAAATGATTTTGAAAATAGTTCTGTTTCATACATGGTATAAGTGAAACAAGGCATAAGGCCCACTCTGCAGGAATTTACCATTGGTTCCTTATTTTAATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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