Basic Information
VIS ID
TVIS44007219
Fusion event
HTLV-1-ARHGAP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
11464659/11446539 (Hg38)
End
11464659/11446539 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP6
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-5088-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/127853; hsa-let-7f-2/Downstream/2143753;
Nearest TSS
ENST00000429181/Upstream/18766; ENST00000478462/Downstream/218544;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/18477, chrX-CpG: 166/Downstream/217674
Upstream sequence
GTGTTTTTTCTCCTTAATTGCTTTTCACTCCTTCTTTTGATGCCCTCCTCAGATAAATTCTCCATGTGACTCACACTGAAAAGAAAAAAAAATGAGAAAT
Downstream sequence
TCTCTTGTAGCCAGAAGAGTTGTTGGCAGAAAGCTGACATTCCGTTCCTTTTCTGTCCTACCAACGTGCACACATTTAATTCCAAAGAATGACTGATGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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