Basic Information
VIS ID
TVIS44007220
Fusion event
HTLV-1-chrX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
21721431/21703313 (Hg38)
End
21721431/21703313 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/1686126; hsa-let-7f-2/Downstream/6792242;
Nearest TSS
ENST00000429181/Upstream/44983; ENST00000465888/Downstream/54709;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/44365, chrX-CpG: 54/Downstream/136160
Nearby gene
SMPX(-2659) ;
Upstream sequence
ACACCTTTAGGTGATGATGTTAAGGCTGCAATCTTATTTTATGGCTGAATCCCCTCTTTTAATAATCGGCATATATATTTTTTTGACTTTGTGTGATTTG
Downstream sequence
CCTTCAGTGTAAGAGCTAAACAAGTTTGGTCATTTGTGTAGAGAAAAAAAATGAGCTCAATACATGACCGCTAAGGATTTTCTTAGCCTGGCAACATCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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