Basic Information
VIS ID
TVIS44007228
Fusion event
HTLV-1-XPNPEP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
128881971/129747995 (Hg38)
End
128881971/129747995 (Hg38)
Orient
-
Location type
Intronic
Target gene
XPNPEP2
miRNAs that regulate target gene
hsa-mir-4502 ; hsa-mir-8069 ; hsa-mir-3682-3p ; hsa-mir-6804-5p ; hsa-mir-1272 ; hsa-mir-885-3p
Nearest miRNA
hsa-let-7f-2/Upstream/8376942; hsa-mir-105-1/Downstream/4421383;
Nearest TSS
ENST00000429181/Upstream/8973; ENST00000476532/Downstream/31984;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/69453, chrX-CpG: 43/Downstream/95569
Upstream sequence
ttgtttaaaatgcagatttcagggccccctccccttgaggagtctgaatcaaaatGTCCTCCGGCCATATTTAGAAAATGTTGGGTTAAAGAATGTTAGG
Downstream sequence
ATTTGAAACAAGATGGAGCAGGAAGGGAGGAAAGAAGGGAAACAGAGAAAGATGAGAGAAAATATCCAACCCCTTTCAAGAGAGAAAAAATCATGATATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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