Basic Information
VIS ID
TVIS44007250
Fusion event
HTLV-1-AIG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
143581542/143260405 (Hg38)
End
143581542/143260405 (Hg38)
Orient
-
Location type
Intronic
Target gene
AIG1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-218-5p ; hsa-mir-3656 ; hsa-mir-3974 ; hsa-mir-340-3p ; hsa-mir-4293 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-4786-5p ; hsa-mir-4802-3p ; hsa-mir-5703 ; hsa-mir-6827-3p ; hsa-mir-6849-3p ; hsa-mir-769-5p
Nearest miRNA
hsa-mir-10398/Upstream/2576522; hsa-mir-1202/Downstream/7842270;
Nearest TSS
ENST00000381078/Upstream/95461; ENST00000367592/Downstream/181572;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/199157, chr6-CpG: 40/Downstream/190068
Upstream sequence
caccgcatctggcGGGTCTTCTGCTTCTTAAAGACACCTCCCCCTATCCCATCCAACTTCTTCAGTTCAGTATATATTGTTGTGTTTGGTGTTTATTAAA
Downstream sequence
TAATTGGAATTTGAATCTATTCTCTGCTTTCCTTTGGAAACCAGTAAATTTTATTCATTCAGTTTTTCATTTATCCATGATAATAGATTCCCTGTTGGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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