Basic Information
VIS ID
TVIS44007252
Fusion event
HTLV-1-WDR91 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
134876040/135191288 (Hg38)
End
134876040/135191288 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR91
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4755-3p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-4781-3p ; hsa-mir-378a-5p ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3923 ; hsa-mir-484 ; hsa-mir-554 ; hsa-mir-6815-3p
Nearest miRNA
hsa-mir-10525/Upstream/1900300; hsa-mir-10399/Downstream/15706;
Nearest TSS
ENST00000635602/Upstream/20493; ENST00000412549/Downstream/2270;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/20344, chr7-CpG: 67/Downstream/19974
Upstream sequence
ATACaagaagctattctagaaaaacacatatactgtggtttattcatatggagtcagaaaacctgcaaaacaaaaattcggttgtttagggatatatagt
Downstream sequence
aattgacatgataaagtaattttttaaatgtaaggcaggccgggtgcagtggctcatgcctgtaatcctagtactttgggaagcccaggtgggtggatca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate