Basic Information
VIS ID
TVIS44007256
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
61682232/59922474 (Hg38)
End
61682232/59922474 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/2617915; hsa-mir-107/Downstream/3450483;
Nearest TSS
ENST00000439456/Upstream/15818; ENST00000619719/Downstream/36197;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/15438, chr10-CpG: 60/Downstream/810553
Nearby gene
CCDC6(-15818) ;
Nearest cancer related gene
CCDC6(OG, -15818) ;
Upstream sequence
acaaggcaaaactaaaaaaaaccaaaaaacataaaacaaaaatcacaaggcacacagataaattaaaaatgcattgcttgatatagaaaaaaataaacag
Downstream sequence
aaactgttcctggaaagatctgatggaggatctactagacaaatatttaaaaacaactgccttaaagatgctcagtgaactaaagaagatgcaaagaaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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