Basic Information
VIS ID
TVIS44007260
Fusion event
HTLV-1-SDHC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
161323246/161353456 (Hg38)
End
161323246/161353456 (Hg38)
Orient
-
Location type
Intronic
Target gene
SDHC
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-9-3p ; hsa-mir-8084
Nearest miRNA
hsa-mir-101-1/Upstream/126195; hsa-mir-1182/Downstream/803651;
Nearest TSS
ENST00000473358/Upstream/29842; ENST00000437833/Downstream/14418;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/38795, chr1-CpG: 77/Downstream/36253
Upstream sequence
CTATTGAAGTTTCAGAGCTTTGTGCTGGCACTGAAATTCAAAAGATAGTTTTGAATTTCCTATCAAAACTACCAAAAGAGGGGTTCCTGCAGTCTTCTAT
Downstream sequence
AATAGCTTATCATCTATCCAGAGTGTCAAAGACTCTGAACCCTCTTGAGTCATATCTTCCTCCcaaatgttcatcaaactgtttgagttcaggtttacct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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