Basic Information
VIS ID
TVIS44007263
Fusion event
HTLV-1-CEP126 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101792897/101922166 (Hg38)
End
101792897/101922166 (Hg38)
Orient
-
Location type
Intronic
Target gene
CEP126
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-129-5p ; hsa-mir-1304-5p ; hsa-mir-193a-5p ; hsa-mir-2467-5p ; hsa-mir-26a-1-3p ; hsa-mir-26a-2-3p ; hsa-mir-3119 ; hsa-mir-3188 ; hsa-mir-3975 ; hsa-mir-4505 ; hsa-mir-485-5p ; hsa-mir-5589-5p ; hsa-mir-5787 ; hsa-mir-6765-5p ; hsa-mir-6878-3p ; hsa-mir-6884-5p ; hsa-mir-8055
Nearest miRNA
hsa-mir-10392/Upstream/402261; hsa-let-7a-2/Downstream/1927740;
Nearest TSS
ENST00000527297/Upstream/5644; ENST00000532529/Downstream/22209;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/6769, chr11-CpG: 39/Downstream/125176
Upstream sequence
gagccaccgcgcccagccTGAGCTCATGATTTCTAAAAGTAGATTTTTTTTCTCCAGGAAAAGTGAGCTATATCTTACTTTCTAATACCAAGTCAGAAtt
Downstream sequence
tttttttttttttttgagatggagtcttgctcttgtcacccagactggagtgcaatggcacaaccttggctcactgcaacctccgcctcccgggttcaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate