Basic Information
VIS ID
TVIS44007280
Fusion event
HTLV-1-ATP9B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77050936/79290936 (Hg38)
End
77050936/79290936 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP9B
Nearest miRNA
hsa-mir-1-2/Upstream/6437554;
Nearest TSS
ENST00000575820/Upstream/36080; ENST00000591518/Downstream/8963;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/65007, chr18-CpG: 60/Downstream/36527
Upstream sequence
TGTTTAACTAGAATCTTCACAAGAAAGTTTATTGCTCTAGGTGCGTGGCATATCTCAGTGTTACCTTTCTTTATATATTAAAATCACTGGCTCCCTTTTG
Downstream sequence
TATGATGGTGTGGTAGAGTTTAGGGGTGAGGCCAATTCACAATTCAGGAATATGTGGTCCGAAACCTCTGCAGCTGTGTCTCAGAAACTGTCTACTCGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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