Basic Information
VIS ID
TVIS44007286
Fusion event
HTLV-1-TAFA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
68583177/68534026 (Hg38)
End
68583177/68534026 (Hg38)
Orient
+
Location type
Intronic
Target gene
TAFA1
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-190a-3p ; hsa-mir-205-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-5580-3p
Nearest miRNA
hsa-let-7g/Upstream/1308499; hsa-mir-12124/Downstream/514932;
Nearest TSS
ENST00000440867/Upstream/116750; ENST00000596659/Downstream/398542;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/526002, chr3-CpG: 106/Downstream/397606
Upstream sequence
TGAAGATGGCCATGTAACATGTCAATCAGAAACAAAATTGGTCTAATGACATCTTCAGAAAGGCAACACTGtgaagaaaactaaaatattttacccgtat
Downstream sequence
atatatgtctttgacatactttgagatggttgttcagagggcttataaacagaagtagcccccaaatctgtctctagtggagacgatttgcatctgtaga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate