Basic Information
VIS ID
TVIS44007301
Fusion event
HTLV-1-RNGTT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
89335811/88626092 (Hg38)
End
89335811/88626092 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6G
Target gene
RNGTT
miRNAs that regulate target gene
hsa-mir-25-3p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-10398/Upstream/10086783; hsa-mir-1202/Downstream/1686650;
Nearest TSS
ENST00000381078/Upstream/205059; ENST00000354922/Downstream/337317;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/458362, chr6-CpG: 60/Downstream/337073
Upstream sequence
gtagagtactgttctaagggttctgcattatttatttaatgctcacaacaaccctatgaagtaggtattaatatccccatttcacagagggaaacagagg
Downstream sequence
catagaggagttatataatttgatcaggggttaatagacagtaaatggtgaagAAGCATATTGTATCCCTACTAAGTAAAAcagtatctaatttaatctg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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