Basic Information
VIS ID
TVIS44007323
Fusion event
HTLV-1-SSX2IP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
85110809/84645126 (Hg38)
End
85110809/84645126 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA1L
Target gene
SSX2IP
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-339-5p ; hsa-mir-92a-3p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-338-3p ; hsa-mir-374a-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-5189-3p ; hsa-mir-4524a-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-101-1/Upstream/7584924; hsa-mir-11399/Downstream/488668;
Nearest TSS
ENST00000473358/Upstream/10106; ENST00000643511/Downstream/7315;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/24033, chr1-CpG: 85/Downstream/44796
Upstream sequence
AAATTCAGAATGGATAAAAACAAATGAAGTACAAAATATTTCAGATTTACATAGTGATAAACAAGAAAGCACTTATCAGGAGGACTTACAAATGGAAGTA
Downstream sequence
CACTCTAGAACCATCATCTATCATGGCTAAATGTGAGATTAGCACAGCTGTATTATTTGTACATTGCAAACACCTAGAAAGAGATGGGAAACAAAATCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate