Basic Information
VIS ID
TVIS44007330
Fusion event
HTLV-1-ZEB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
31634037/31345108 (Hg38)
End
31634037/31345108 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZEB1
miRNAs that regulate target gene
hsa-mir-141-3p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-205-5p ; hsa-mir-200a-3p ; hsa-mir-200b-3p ; hsa-mir-150-5p ; hsa-mir-130b-3p ; hsa-mir-335-5p ; hsa-mir-101-3p ; hsa-mir-23b-3p ; hsa-mir-591 ; hsa-mir-629-5p ; hsa-mir-203a-3p ; hsa-mir-494-3p ; hsa-mir-539-5p ; hsa-mir-655-3p ; hsa-mir-1236-3p ; hsa-mir-183-5p ; hsa-mir-96-5p ; hsa-mir-142-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-133a-3p ; hsa-mir-144-3p ; hsa-mir-590-3p ; hsa-mir-409-3p ; hsa-mir-33b-5p ; hsa-mir-484 ; hsa-mir-652-3p ; hsa-mir-10b-5p ; hsa-mir-223-3p ; hsa-mir-455-3p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-2052 ; hsa-mir-3149
Nearest miRNA
hsa-mir-1265/Upstream/976443; hsa-mir-107/Downstream/3734490;
Nearest TSS
ENST00000439456/Upstream/23098; ENST00000560909/Downstream/10036;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/23943, chr10-CpG: 60/Downstream/258153
Upstream sequence
CATTTAAAAATTTATCCAGATGTTAATGTTTGACTGGAAGTTTTCTACTGGAAGAATTAGTTTGGATTTTACAATTTGGGAGAGGCAGAAGGGAGTTGGG
Downstream sequence
GAGGTGGTCAAGCCCAAATTAGCATGTTGAATATCCAGATTCACAGACATTTCACTAAACCATTTATGTACTTAGCATTTTTGTTGACTAGTCTTTTCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate