Basic Information
VIS ID
TVIS44007332
Fusion event
HTLV-1-ZNF503 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
77055811/75296053 (Hg38)
End
77055811/75296053 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ZNF503
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-3p ; hsa-mir-331-3p ; hsa-mir-181b-5p ; hsa-mir-92a-3p ; hsa-mir-3692-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-8068 ; hsa-mir-5087 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-153-5p
Nearest miRNA
hsa-mir-1265/Upstream/2574953; hsa-mir-107/Downstream/256405;
Nearest TSS
ENST00000439456/Upstream/12252; ENST00000526759/Downstream/330;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/728, chr10-CpG: 983/Downstream/99317
Upstream sequence
GTTGGGCTTGGCTATAACTCTACAAGTAAAACAGTCACCCCGAGCAATACGTACAGGAACTCAATAGTAACGTGATTAAGTTCCTAGTCAACAAGACTAC
Downstream sequence
ACTCGACTGTATGTTAACAAACCTAATTATAGCCCCGTGGTAATAAATTGGGCCAGGGCCCTGGCTGCACATCTCTGAGGTCATGTCTAGGAGAGCTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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