Basic Information
VIS ID
TVIS44007340
Fusion event
HTLV-1-AEBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
19569200/19416266 (Hg38)
End
19569200/19416266 (Hg38)
Orient
-
Location type
Intronic
Target gene
AEBP2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-484 ; hsa-mir-328-3p ; hsa-let-7e-5p ; hsa-mir-3686 ; hsa-mir-4775 ; hsa-mir-3607-3p ; hsa-mir-4778-5p ; hsa-mir-5580-3p ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/1742872; hsa-let-7i/Downstream/4796155;
Nearest TSS
ENST00000382841/Upstream/12200; ENST00000360995/Downstream/23408;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/109495, chr12-CpG: 147/Downstream/22983
Nearby gene
AEBP2(+23408) ;
Upstream sequence
gtgaaaccttgtctTTAAaaaacaaaagaaaacaaaacaaaacCCAACTTTggttacttgtatctgccaaacagaatttatctaaaagtcattcatgtcc
Downstream sequence
aaattggttcaggttagtttggaataATAGGATTTGCATATAATTGGTATTCAATATTGCTCATTACTTCCATTTCTAAGTTTTGAGCTTTTTGCTATTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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