Basic Information
VIS ID
TVIS44007348
Fusion event
HTLV-1-LRRC63 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46805056/46230921 (Hg38)
End
46805056/46230921 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRRC63
miRNAs that regulate target gene
hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-561-3p ; hsa-mir-548at-5p
Nearest miRNA
hsa-mir-2276/Upstream/2034721; hsa-mir-1267/Downstream/3765494;
Nearest TSS
ENST00000623511/Upstream/17886; ENST00000612699/Downstream/66923;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/178037, chr13-CpG: 93/Downstream/155628
Upstream sequence
cattgctttgctcccacatctgagcataggctgttacaagcagccaggccaaatcttgaatgctttgctgcttagaaatttcttctatcagataccccaa
Downstream sequence
gtcatcactctgaagttcagacttccacagatcattaggacatgaatagaatttagccaagctctttgctaaggtgtaacatgggtgacttttgctccag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate