Basic Information
VIS ID
TVIS44007379
Fusion event
HTLV-1-AXIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
63539012/65542894 (Hg38)
End
63539012/65542894 (Hg38)
Orient
-
Location type
Intronic
Target gene
AXIN2
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-34a-3p ; hsa-mir-34b-5p ; hsa-mir-34c-3p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-6501-3p ; hsa-mir-4496 ; hsa-mir-424-5p ; hsa-mir-2278 ; hsa-mir-195-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-15a-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-1246 ; hsa-mir-582-3p ; hsa-mir-374a-3p
Nearest miRNA
hsa-mir-10226/Upstream/720792; hsa-mir-1250/Downstream/1244178;
Nearest TSS
ENST00000595228/Upstream/6212; ENST00000583775/Downstream/15835;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/5079, chr17-CpG: 215/Downstream/16890
Nearest cancer related gene
AXIN2(TSG, No orient, 0)
Upstream sequence
AATGAATCATACTTGGAGGCTGTAAATATTGAAATTGGGTGTTTGGCTACTTCCCTTTCCCCAATGTCTGGTTCATCATAGGGTGGAAGAAAAATAGGAT
Downstream sequence
AATTAGCAATGTCTAAAAATACCCAGGGGGCAAGCCAGGAGTAACTAGTCAACCTCTAGCTCCTTATCTGAAATGCCCTAGAATTCTAAATAGCTGCATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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