Basic Information
VIS ID
TVIS44007383
Fusion event
HTLV-1-CCDC68 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
52613938/54946707 (Hg38)
End
52613938/54946707 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
CCDC68
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p
Nearest miRNA
hsa-mir-1-2/Upstream/1709517; hsa-mir-122/Downstream/532514;
Nearest TSS
ENST00000575820/Upstream/3757; ENST00000587660/Downstream/11341;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/117931, chr18-CpG: 39/Downstream/12579
Upstream sequence
GAAAATTGCATCGGGCCTTATGTCTTTTATCCTAAAATATACTCTCTTATGTACCTTTTATTCTTAAAATCAAGGAATTTTGTTTCTTGATGACTGATAT
Downstream sequence
TTCTGAAAACTtcccaccttttccactcactggttgggccaccttaaacaagttacataaaatctttgtcttcacttacatagctgtcaggtaggggtga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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