Basic Information
VIS ID
TVIS44007406
Fusion event
HTLV-1-chr21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
24787557/23415237 (Hg38)
End
24787557/23415237 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105372747 ; LOC107985512
Nearest miRNA
hsa-let-7c/Upstream/335845; hsa-mir-155/Downstream/2158743;
Nearest TSS
ENST00000624081/Upstream/30376; ENST00000433101/Downstream/62404;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2416992, chr21-CpG: 28/Downstream/1946557
Nearby gene
D21S2088E(-30401) ;
Upstream sequence
TTGTTACTTTCATCTAAAGAGATGTCAGTTTTAAGTTTTATGGAACaatatttttaaaatattaatattaacttataaaatGGCAATTTTAGTAGAAACT
Downstream sequence
AAAGGATTATTGTCTTTAAAAATATTGATAGGAATATGATTGTGTTAAAATATTTTGTGTTCAGAATATGAGTAATACATTTATTAAAAATAAACATTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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