Basic Information
VIS ID
TVIS44007410
Fusion event
HTLV-1-SPATC1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
47585466/46165552 (Hg38)
End
47585466/46165552 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPATC1L
miRNAs that regulate target gene
hsa-mir-625-5p
Nearest miRNA
hsa-let-7c/Upstream/687226;
Nearest TSS
ENST00000624081/Upstream/9985; ENST00000415026/Downstream/18907;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/3401, chr21-CpG: 16/Downstream/15554
Upstream sequence
ccaatgcttgtaacctctgtgttgtaccctccaaagaaaaggacaacatgagtatgaggagtcctttctctcctcctagcctctcctgtagaagccttct
Downstream sequence
gacttAgatatgagtatgagtcctttccctcctcttagcctctcctatagaaaccttctgactagaaaaggacaacatgagtatgaggagtcctttccct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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