Basic Information
VIS ID
TVIS44007416
Fusion event
HTLV-1-BEND4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
42138421/42136404 (Hg38)
End
42138421/42136404 (Hg38)
Orient
-
Location type
Intronic
Target gene
BEND4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6499-3p ; hsa-mir-505-5p ; hsa-mir-6814-5p ; hsa-mir-4530 ; hsa-mir-6733-3p ; hsa-mir-6858-3p ; hsa-mir-4519 ; hsa-mir-4428 ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-505-3p ; hsa-mir-202-3p ; hsa-mir-520g-5p ; hsa-mir-3163 ; hsa-mir-551b-5p ; hsa-mir-4668-3p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-3671 ; hsa-mir-4672 ; hsa-mir-664a-3p ; hsa-mir-5680 ; hsa-mir-6768-5p ; hsa-mir-944 ; hsa-mir-3121-3p ; hsa-mir-101-3p ; hsa-mir-376b-3p ; hsa-mir-376a-3p
Nearest miRNA
hsa-mir-12113/Upstream/1634285; hsa-mir-1243/Downstream/5516265;
Nearest TSS
ENST00000502981/Upstream/66215; ENST00000645181/Downstream/14624;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/145296, chr4-CpG: 219/Downstream/14345
Upstream sequence
TGACATGATTGATCATTTTAAAACCTTCTTAATTAGAAAATGTCAACAGTGGACTAACATGATCAGAACTGCAGAATCCAAGGTTAGTTCTCTAGTTTGT
Downstream sequence
AGCCTCTGGAGTTGGTAcagtgggtcctcatcattcatggattcggtatttgcaaatttgctttacttaccaaaatgtatttgtaacccccaaatcagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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