Basic Information
VIS ID
TVIS44007419
Fusion event
HTLV-1-USP53 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
120139730/119218575 (Hg38)
End
120139730/119218575 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP53
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-16-5p ; hsa-mir-186-3p ; hsa-mir-323a-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-876-3p ; hsa-mir-374b-3p ; hsa-mir-548j-5p ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-4456 ; hsa-mir-548ak ; hsa-mir-4524a-5p ; hsa-mir-548am-5p ; hsa-mir-3973 ; hsa-mir-4690-3p ; hsa-mir-548ap-5p ; hsa-mir-4524b-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-5685 ; hsa-mir-548ay-5p ; hsa-mir-548bb-5p ; hsa-mir-545-3p ; hsa-mir-3120-3p ; hsa-mir-6504-3p ; hsa-mir-6792-5p ; hsa-mir-6806-5p ; hsa-mir-646 ; hsa-mir-6838-5p ; hsa-mir-503-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6757-3p ; hsa-mir-15a-5p ; hsa-mir-497-3p ; hsa-mir-141-3p ; hsa-mir-200a-3p
Nearest miRNA
hsa-mir-12113/Upstream/4561721; hsa-mir-1305/Downstream/6288684;
Nearest TSS
ENST00000502981/Upstream/5396; ENST00000507906/Downstream/20641;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5441, chr4-CpG: 40/Downstream/81896
Upstream sequence
ACACAAAGAAATAGAGCAAAAAAGTGGAAACATTGAAAATTACTTAAAACTTACTGTTTTTTTGTTGGCAGTATTATAGTCTTTTTTCTTATTAATTTTA
Downstream sequence
TTTTCTGTGTTTTATAAATTTTCTACTGTAGTCTTCTCTAATTCCTCCATTTCTAGAGTGACAATGGTTTTACACATCAAAGAATATTTATTCTTCAATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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