Basic Information
VIS ID
TVIS44007425
Fusion event
HTLV-1-KCNN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113474886/114139189 (Hg38)
End
113474886/114139189 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNN2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/3625274; hsa-mir-103a-1/Downstream/2116554;
Nearest TSS
ENST00000502646/Upstream/83183; ENST00000505491/Downstream/221756;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/82881, chr5-CpG: 180/Downstream/221954
Nearby gene
KCNN2(+223130) ;
Upstream sequence
AATGTCTCATAATGGAGGACAGCATATTTAGTAACTAATCCATTTACATGGCAacctctctgttatttgattcctaatttggagttttctgtcttacttg
Downstream sequence
gctagaatacatctaaaagtatttttgaagaagacatgtggatagtgttttttgcatacttgataattttgtggtgttgttttctcataagaataaatga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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