Basic Information
VIS ID
TVIS44007436
Fusion event
HTLV-1-ADGRB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
69666997/68957105 (Hg38)
End
69666997/68957105 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRB3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/11566893; hsa-mir-10524/Downstream/2419855;
Nearest TSS
ENST00000381078/Upstream/318429; ENST00000604969/Downstream/275301;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/321951, chr6-CpG: 53/Downstream/839295
Upstream sequence
TGTTTGTGGAGATTACAAAACAAGTTGCCTTAGGATATATATACTGGAAATGTAAAGACATAAGAAATGAATGAGAAGATAAAGAAGTGTCGCTGACATT
Downstream sequence
CAGATGCTTTTAAGTTCTGTTGCTAATTACTCTGACCTTGATGTGTGACCTTGATTATCTACATTTACTTGCGTTTGCCCCATTTTTCATTGGCAAAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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