Basic Information
VIS ID
TVIS44007451
Fusion event
HTLV-1-BAZ1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
72859938/73445608 (Hg38)
End
72859938/73445608 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
BAZ1B
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-21-5p ; hsa-let-7b-5p ; hsa-mir-505-5p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-30b-5p ; hsa-mir-100-5p ; hsa-mir-16-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-1183/Upstream/747630; hsa-mir-10399/Downstream/265709;
Nearest TSS
ENST00000635602/Upstream/11825; ENST00000324941/Downstream/20779;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/9906, chr7-CpG: 139/Downstream/75674
Upstream sequence
ACGTAGAAGTGGAAAGCAATCACTAGCTTACAAATAAACAGAATCAGTATACTACCATATTCAGGATCTGCCCTCAGAGAGATcaggcgcagtggctcac
Downstream sequence
acttgtaatcccagcacttcgggaggccaaggcaggaggatcacttgaacccaagagttcaagaccagcctgggaaacatggcaagaccctatctctaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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