VISDB - VIS Detail

Basic Information

VIS ID

TVIS44007453

Fusion event

HTLV-1-KIAA1549 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

q34

Reference genome

GRCh37/hg19

Start

138581721/138896975 (Hg38)

End

138581721/138896975 (Hg38)

Orient

Location type

Intronic

Target gene

KIAA1549

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-4705 ; hsa-mir-218-5p ; hsa-mir-4701-5p ; hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-500b-3p ; hsa-mir-1266-3p ; hsa-mir-888-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-1306-5p ; hsa-mir-1303 ; hsa-mir-3674 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-7156-3p ; hsa-mir-6861-3p ; hsa-mir-1184 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p ; hsa-mir-4700-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-4698 ; hsa-mir-6504-3p ; hsa-mir-4438

Nearest miRNA

hsa-mir-10525/Upstream/773154; hsa-mir-10399/Downstream/147125;

Nearest TSS

ENST00000635602/Upstream/97415; ENST00000479132/Downstream/84343;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/27222, chr7-CpG: 150/Downstream/83990

Upstream sequence

caggtgtgagccaccacacctgcccTCTTCTTACTCTAACCTAGGAAAACCCTGATGAGGCAGAGGTTGATCAAACTGGACCCTGACACCAGTGTCCTGG

Downstream sequence

GGCTGCCTTTGGGCTATCCCTGGTGTTGGCTGAGGCTTCCTTCAATCGCCATCCCTGAGATCCCAGGATCTTTACCCACGTGGTTTTCGGTACAAAACTG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.