Basic Information
VIS ID
TVIS44007458
Fusion event
HTLV-1-UBXN8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
30614289/30756772 (Hg38)
End
30614289/30756772 (Hg38)
Orient
+
Location type
Exonic
Target gene
UBXN8
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-124-1/Upstream/799424; hsa-mir-10400/Downstream/10514276;
Nearest TSS
ENST00000518652/Upstream/653; ENST00000613013/Downstream/6374;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/28638, chr8-CpG: 41/Downstream/55162
Upstream sequence
AGGGTAAAAAAAGGAAAAAGGAAAAACAATTGTGAATAGAATAAAGTTGATAGAAAACATCTCTTTAGAAATTGTCTGTTGTGTTTGACCAGGGTGATGA
Downstream sequence
AGGTACAAGTCAGACATCTTTTGAAACATCAAACAGAGAAGCAGCAAAGAGCCAGAACTTGCCTAAACCTTTAACTGAATTTCCGTCTCCTGCTGAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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