Basic Information
VIS ID
TVIS44007464
Fusion event
HTLV-1-THEM6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
143814477/142733059 (Hg38)
End
143814477/142733059 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
THEM6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-877-5p ; hsa-mir-4451 ; hsa-mir-6809-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-765 ; hsa-mir-6499-3p ; hsa-mir-4708-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-17-3p ; hsa-mir-194-3p ; hsa-mir-3922-5p ; hsa-mir-1296-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4695-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418
Nearest miRNA
hsa-mir-1204/Upstream/556641; hsa-mir-10400/Downstream/1000024;
Nearest TSS
ENST00000518652/Upstream/5336; ENST00000518798/Downstream/1471;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/5167, chr8-CpG: 81/Downstream/5991
Upstream sequence
gacatttttacttcctgcagaaaggacacacttgccatcagctttgccacaagagttcacccaacaaaggaaacagggtcatttataacctgacgcgtcc
Downstream sequence
accctattgccgtctctggtttccattgactgggatgggacctcacattctgtatctgtcccgattggctagcaacgtacaactttttaaaagaggcaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate