Basic Information
VIS ID
TVIS44007466
Fusion event
HTLV-1-DENND4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
19350642/19350644 (Hg38)
End
19350642/19350644 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND4C
miRNAs that regulate target gene
hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-4775 ; hsa-mir-550b-2-5p ; hsa-mir-1227-3p ; hsa-mir-5189-3p ; hsa-mir-4714-3p ; hsa-mir-7849-3p ; hsa-mir-590-3p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-33a-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-302f ; hsa-mir-5692a ; hsa-mir-633 ; hsa-mir-223-5p ; hsa-mir-496 ; hsa-mir-4781-3p ; hsa-mir-1304-3p ; hsa-mir-215-3p ; hsa-mir-3664-5p ; hsa-mir-3672 ; hsa-mir-4639-3p ; hsa-mir-6773-3p ; hsa-mir-6794-3p ; hsa-mir-6864-3p ; hsa-mir-6879-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-101-2/Upstream/777265; hsa-let-7a-1/Downstream/1060504;
Nearest TSS
ENST00000422679/Upstream/3916; ENST00000609982/Downstream/21301;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/119324, chr9-CpG: 48/Downstream/29152
Upstream sequence
TGAAATAATAGTGAGGAGATTTCATGGTTTTGAAAAATGTGGGGATGATGATTTGTTTAAGGATTATAGAGTTTAATTTTGAAAAGGGTAGAGTGGGTAT
Downstream sequence
AATCCCACTGGAGAAGGTATTATTTATGTATGTGGAATTTTTTTTTTTCAATTAAAGGAAGAAACTAATAGAGACTACAGCTTCCCAGCTGGCCTAGAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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