Basic Information
VIS ID
TVIS44007472
Fusion event
HTLV-1-NOL8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95069383/92307101 (Hg38)
End
95069383/92307101 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOL8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-186-5p ; hsa-mir-1260b
Nearest miRNA
hsa-mir-101-2/Upstream/14554; hsa-let-7a-1/Downstream/220883;
Nearest TSS
ENST00000422679/Upstream/7075; ENST00000618653/Downstream/1849;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/13084, chr9-CpG: 64/Downstream/18566
Upstream sequence
AGCAGTTTTCTTTTCATTTACCTCTTTGAGGAAAAGGGATAATTAATACTCTCTTGGAAAACACAGCCTGAGAAGTCTCAATCATCAAATATTTACCAAG
Downstream sequence
TACCTAAACATGTTCAAAATCCATTAAGACAGGAAGAAGAAACTTTAACCTCATTTCACTAACCTCCATAACCAAAGACCCTCAGTCATAGCAAACTCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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