Basic Information
VIS ID
TVIS44007475
Fusion event
HTLV-1-CLDN34 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
9935766/9967726 (Hg38)
End
9935766/9967726 (Hg38)
Orient
-
Location type
Exonic
Target gene
CLDN34
Nearest miRNA
hsa-mir-3690-1/Upstream/1840665; hsa-let-7f-2/Downstream/1350888;
Nearest TSS
ENST00000429181/Upstream/368; ENST00000466248/Downstream/47836;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/22798, chrX-CpG: 19/Downstream/24439
Upstream sequence
ACGCTTCCTACTGACTGCCAGCATTTTCGGATTCTTCGGGAGAGCCTTTAACATGTTTGCACTTAGAAACATGTCCATGAGAATGTTTGAGGAGGACACC
Downstream sequence
TACAATTCATTCGTTGTTTCAGGAATTCTCAACATTGCTGCTGGTGTCTTTAACTTAATTGCTGTGCTCCAGAACTACGATGCCGTCATAAACTCACAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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