Basic Information
VIS ID
TVIS44007480
Fusion event
HTLV-1-TRPC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
111058027/111814799 (Hg38)
End
111058027/111814799 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRPC5
miRNAs that regulate target gene
hsa-mir-29b-2-5p ; hsa-mir-320a ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-4313 ; hsa-mir-3941 ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-6890-3p ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-32-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1732581; hsa-mir-105-1/Downstream/965919;
Nearest TSS
ENST00000429181/Upstream/54987; ENST00000635763/Downstream/61252;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/132752, chrX-CpG: 19/Downstream/267055
Upstream sequence
ATCCCCATCCTCAGGCATGAAAGGGCTGCTAATCCCCCTCCCAAATTATGGTTTCTAGGTGGTTGGGGTCACTGCTCTGACCATTTGAGGACTTGGCGTG
Downstream sequence
TGTTACTTTTTTTTACTAGTACTCAGCTTCCAGCCTTTTTAACCACCTCAGCTCCAGTGTGCAAACTCAGGTGCTACACTTCAGGGCAAACCTCAGAACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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