Basic Information
VIS ID
TVIS44007484
Fusion event
HTLV-1-POLE4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75194695/74967568 (Hg38)
End
75194695/74967568 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
POLE4
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-7-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/4714563; hsa-mir-10b/Downstream/123244;
Nearest TSS
ENST00000437798/Upstream/8457; ENST00000604271/Downstream/153198;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8518, chr2-CpG: 96/Downstream/231898
Upstream sequence
gtattttgaagtttgtcttttagttctgtaaacatagtaaacacagttgttttatagtgaatgttccatccaatatatgacctaatattcaaagcctttt
Downstream sequence
gagttttttgtttgctagtctgtgccgaatctaacatccatagtctcttgagactgtctttttgtctgttgtttcttttggtactgtcacatggcctttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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