Basic Information
VIS ID
TVIS44007491
Fusion event
HTLV-1-chr6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
46126730/46158993 (Hg38)
End
46126730/46158993 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-10398/Upstream/961223; hsa-mir-10524/Downstream/5985356;
Nearest TSS
ENST00000381078/Upstream/29000; ENST00000415787/Downstream/8558;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/28777, chr6-CpG: 58/Downstream/332148
Nearby gene
ENPP5(-189) ;
Upstream sequence
AACTGCAGGTGATGGAGAAGAAATTGTAAAATACAAACTGAATTTTAAAAAATCCTAACAATTAATAAACTTTACAAAATGGCTCATGTAGGAGGATGTT
Downstream sequence
GAGAAAAGATGGGGGCACAGAGAGAAGCTCCATTCCTCTGACCTTTCTAAAATTCTTACAATTAGTAAGATTAGCTAGTCTTTTATTTCCATGTACTAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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