Basic Information
VIS ID
TVIS44007492
Fusion event
HTLV-1-ASTN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
119466000/116703721 (Hg38)
End
119466000/116703721 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E ; FRA9B
Target gene
ASTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p
Nearest miRNA
hsa-let-7a-1/Upstream/2494192; hsa-mir-12126/Downstream/3541258;
Nearest TSS
ENST00000422679/Upstream/16378; ENST00000450938/Downstream/510832;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/16233, chr9-CpG: 163/Downstream/709254
Upstream sequence
tgctagatgacgagttagtgggtgcagcgcaccagcatggcacatgtatacgtatgtaactaacctgcacaatgtgcacatgtaccctaaaacttaaagt
Downstream sequence
ataataataaaaaaaaaaAAAGTGCAGTGTTACTCTACTCTGTAGGAGGGAAGTGGAAGGGAGAACCTAGTATGAGACTCAGGTCTCCACCCTGCACTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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