Basic Information
VIS ID
TVIS44007497
Fusion event
HTLV-1-ADCY2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
7709345/7709232 (Hg38)
End
7709345/7709232 (Hg38)
Orient
-
Location type
Exonic
Target gene
ADCY2
miRNAs that regulate target gene
hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-4680-5p ; hsa-mir-7114-5p ; hsa-mir-4539 ; hsa-mir-146a-3p ; hsa-mir-4714-5p ; hsa-mir-4318 ; hsa-mir-4643 ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-4277/Upstream/881311; hsa-mir-10397/Downstream/751693;
Nearest TSS
ENST00000502646/Upstream/24141; ENST00000382531/Downstream/40534;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/312685, chr5-CpG: 112/Downstream/140600
Upstream sequence
TCCAATGAGGTCGATGCCAAAAGGATCATGTGTGGCCCTGTGCTGTGCCAGGTGTGATGCTTTGTTTCTCACCCCAAGGGAGAACGACGGAGCCCCCAGC
Downstream sequence
ATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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