Basic Information
VIS ID
TVIS44007509
Fusion event
HTLV-1-AKR1B10P1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
69510200/67750442 (Hg38)
End
69510200/67750442 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
AKR1B10P1
Nearest miRNA
hsa-mir-1265/Upstream/347032; hsa-mir-107/Downstream/4040305;
Nearest TSS
ENST00000439456/Upstream/54273; ENST00000610279/Downstream/87617;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2696139, chr10-CpG: 39/Downstream/13643
Nearby gene
DNAJC12(-46227) ;
Upstream sequence
TTGGAAGTCTCCTCTCGGCAAAGTGAAAGAAGTGGTGAAGGTGGCCATTGATGCAGGATATCGCCACATTGACTGTGCCTATGTCTATCAGAATGAACAT
Downstream sequence
GAGGTGGGGGAAGCCATCCAAGAGAAGATCCAAGAGAAGGCTGTAAAGCGGGAGGACCTCTTCATCATCAACAAGTTGTGGCCCACTTTCTTTGAGAGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate