Basic Information
VIS ID
TVIS44007518
Fusion event
HTLV-1-KIF7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
90203584/89660353 (Hg38)
End
90203584/89660353 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIF7
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-342-5p
Nearest miRNA
hsa-mir-10393/Upstream/292247; hsa-mir-1302-10/Downstream/190284;
Nearest TSS
ENST00000557528/Upstream/4902; ENST00000558000/Downstream/7287;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/4751, chr15-CpG: 53/Downstream/5203
Nearby gene
PLIN1(-4016) ;
Nearest cancer related gene
KIF7(TSG, No orient, 0)
Upstream sequence
cagagattacaagttacccccatccctgggatctacttcccctccatttaggacttctgatttttaattaggtgcatagccactccagatgaaaactata
Downstream sequence
tttcccatcccccttttaaaccaggagtggtcatgtgactaagttctgtccagtgggttataagcagaagtagttgtaatttctggtgtggaggcatgcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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