Basic Information
VIS ID
TVIS44007520
Fusion event
HTLV-1-WWOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
78412776/78378879 (Hg38)
End
78412776/78378879 (Hg38)
Orient
+
Location type
Intronic
Target gene
WWOX
Nearest miRNA
hsa-mir-1225/Upstream/1509860; hsa-mir-11401/Downstream/3006139;
Nearest TSS
ENST00000527434/Upstream/137661; ENST00000620008/Downstream/45992;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/278710, chr16-CpG: 44/Downstream/1210715
Nearest cancer related gene
WWOX(TSG, No orient, 0)
Upstream sequence
GAGTGTAGATTATTGCCGTGCTTACATTTTCTCCTTCAGCGGTAACACTTCTCTTGTAAATTCTAACTGGGTAAAATAAATATGATATAAAACAGACACA
Downstream sequence
AATAAGAATATATAGATGATGTTAATTTCTTCAGAGCTTCCCGGTGTTACGTCTTCAAGAATATGACGAcaggggaacagcccagtgtggcagtcatgtg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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