Basic Information
VIS ID
TVIS44007539
Fusion event
HTLV-1-RAB5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
20024285/19982793 (Hg38)
End
20024285/19982793 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAB5A
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-33a-5p ; hsa-mir-18a-5p ; hsa-mir-451a
Nearest miRNA
hsa-mir-12127/Upstream/667862; hsa-let-7g/Downstream/154772;
Nearest TSS
ENST00000440867/Upstream/7277; ENST00000426228/Downstream/29464;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/34964, chr3-CpG: 96/Downstream/57173
Upstream sequence
caggactgcagtaagccatgatcataccactgcacttaatcctgggtgacagagtgagaccttgtctcttaaaaaaaaaaaaaaaGAGAGCATGTATATA
Downstream sequence
GATGTTTTAAGGCCAAAGGCTGTGGAAGCCAGGAAGGAAATAGTAGATATGATCTATCACAATTCGGGGTGATAATTAGTTGCACAGTAGAGGACAAGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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