Basic Information
VIS ID
TVIS44007542
Fusion event
HTLV-1-chr3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh37/hg19
Start
156853236/157135447 (Hg38)
End
156853236/157135447 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/5569452; hsa-mir-1224/Downstream/2147199;
Nearest TSS
ENST00000440867/Upstream/12443; ENST00000480817/Downstream/14186;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/14811, chr3-CpG: 106/Downstream/23939
Nearby gene
CCNL1(-11055) ;
Nearest cancer related gene
CCNL1(OG, -11055) ;
Upstream sequence
TTCATCATCAATGAATATTTATGAAGTGCCCACATGGAGGTTGCTTGCCAGTTCCGAACCCAGATAAGAGGGAAGGTTCTTTATTCTGTTGCAGAGGGGC
Downstream sequence
GTTTAGTCAGTAAACTGCATTTCTTTTAACTTCTGAAAGCCTTCCTTTTTTCTGGGGAAAAAAATGTCATTTTGCTTTTGCAAATGAGAGAGTAAAGCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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