Basic Information
VIS ID
TVIS44007556
Fusion event
HTLV-1-AKAP9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
91719606/92090292 (Hg38)
End
91719606/92090292 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7E
Target gene
AKAP9
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-10525/Upstream/16175023; hsa-mir-10399/Downstream/113723;
Nearest TSS
ENST00000635602/Upstream/6716; ENST00000487692/Downstream/1697;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/149258, chr7-CpG: 115/Downstream/43489
Nearest cancer related gene
AKAP9(OG, No orient, 0)
Upstream sequence
ctgtaacattcttccaacattcttccaagttactgcatttttcaagttactgcattcttccaaattagtagtagaacattcttccaagttactgcattta
Downstream sequence
tctctagttcattcattcttgttactctataactctatgaccctgtgtagggccaggcacggtggcttacacctgtaatcccagcactttgggaggctga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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